Project Researcher, Shenzhen Institute of Geriatrics, China.

Speech Title: Study on synthesis and properties of nanoparticles loaded amaryllidaceous alkaloids
Abstract: Alzheimer disease (AD) is the most common disease among the elderly people and a major social and medical problem. Amaryllidaceous alkaloids, as acetylcholinesterase inhibitors, have the potential intreatment of AD. However, it also has some shortages, such as the extensive toxicity and side effect, widely spread in the body. In order to improve the bioavailability and reduce the toxic and side effect, the brain targeting of amaryllidaceous alkaloids was enhanced by considering low density lipoprotein (LDL) receptors of BBB endothelial cells as therapeutic targets in the paper. Then, amaryllidaceous alkaloids were high selectively and quantitatively riveted to the surface of low density lipoprotein by using a new method- the mild click chemistry. The structure of products had been characterized by NMR, FT-IR and so on. In addition, drug loading rate, encapsulation rate and drug release of the nanoparticles were determined to assess the quality of the nanoparticles.
Keywords: Alzheimer disease；Amaryllidaceous alkaloids；Low density lipoprotein；Click chemistry